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  • A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent

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Clinical science
Scientific reports
A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent
  1. D Wong1,
  2. J C Van Meurs2,
  3. T Stappler1,
  4. C Groenewald1,
  5. I A Pearce1,
  6. J N McGalliard1,*,
  7. E Manousakis1,
  8. E N Herbert1
  1. 1St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
  2. 2The Rotterdam Eye Hospital, Schiedamsevest 180, 3011 BH, Rotterdam, Netherlands
  1. Correspondence to: Mr David Wong St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK; shdwongliv.ac.uk

Abstract

Aims: To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade.

Methods: 42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture.

Results: The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation.

Conclusion: This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.

  • ERM, epiretinal membranes
  • PFCL, perfluorocarbon liquids
  • PPV, pars plana vitrectomy
  • PVR, proliferative vitreoretinopathy
  • RD, retinal detachments
  • SiO, silicone oil
  • perfluorohexyloctane
  • silicone oil
  • proliferative vitreoretinopathy
  • retinal detachment
  • ERM, epiretinal membranes
  • PFCL, perfluorocarbon liquids
  • PPV, pars plana vitrectomy
  • PVR, proliferative vitreoretinopathy
  • RD, retinal detachments
  • SiO, silicone oil
  • perfluorohexyloctane
  • silicone oil
  • proliferative vitreoretinopathy
  • retinal detachment

https://doi.org/10.1136/bjo.2004.055178

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    Footnotes

    • ↵* Deceased.

    • The authors have no financial interest in the product Densiron.

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