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Br J Ophthalmol 2005;89:662-665 doi:10.1136/bjo.2004.055178
  • Clinical science
    • Scientific reports

A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent

  1. D Wong1,
  2. J C Van Meurs2,
  3. T Stappler1,
  4. C Groenewald1,
  5. I A Pearce1,
  6. J N McGalliard1,*,
  7. E Manousakis1,
  8. E N Herbert1
  1. 1St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
  2. 2The Rotterdam Eye Hospital, Schiedamsevest 180, 3011 BH, Rotterdam, Netherlands
  1. Correspondence to: Mr David Wong St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK; shdwongliv.ac.uk
  • Accepted 7 September 2004

Abstract

Aims: To report a prospective two centred non-comparative interventional pilot study of a solution of perfluorohexyloctane and silicone oil (Densiron-68) as a heavier than water internal tamponade.

Methods: 42 consecutive patients were recruited. The indications include proliferative vitreoretinopathy, retinal detachments arising from inferior retinal breaks, and inability to posture.

Results: The success rate with one operation using Densiron was 81% and with further surgery 93%. At the end of the study all tamponade agents were removed in 90% of patients. Visual acuity improved from mean logMAR of 1.41 (SD 0.64) to 0.94 (SD 0.57), p = 0.001. There was little evidence of dispersion and excessive inflammation.

Conclusion: This new tamponade agent is being compared to conventional silicone oil in a prospective international randomised trial.

Footnotes

  • ↵* Deceased.

  • The authors have no financial interest in the product Densiron.

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