Article Text
Abstract
Aim: To investigate the serum levels of prorenin and its correlation with the severity of diabetic retinopathy (DR).
Methods: 248 patients with diabetes and 108 control subjects were divided into four groups: no-DR (n = 146), no proliferative diabetic retinopathy (no-PDR) (n = 78), PDR (n = 24), and controls (n = 108). Serum levels of prorenin from all subjects were measured using the new antibody activating direct kinetic (AAD-PR) assay. The serum prorenin levels were compared among the groups.
Results: The serum levels of prorenin in the control, no-DR, no-PDR, and PDR groups, respectively, were 109.1 (66.1), 194.6 (160.4), 271.5 (220.3), and 428.4 (358.4) pg/ml (mean (SD)). Prorenin in the PDR group was remarkably high compared with the control and no-DR groups (p<0.0001) and with the no-PDR group (p = 0.002). Serum levels of prorenin increased with increasingly severe retinopathy. No correlation was found between the prorenin level and the duration of disease or HbA1c.
Conclusions: The serum levels of prorenin in patients with PDR were found to be markedly high using the AAD-PR assay. Increased levels of prorenin in diabetes may have an important role in the pathogenesis of DR.
- AAD-PR, antibody activating direct prorenin
- DR, diabetic retinopathy
- PDR, proliferative diabetic retinopathy
- RAS, renin-angiotensin system
- antibody activating direct prorenin assay
- diabetes
- diabetic retinopathy
- prorenin
- renin-angiotensin system
- AAD-PR, antibody activating direct prorenin
- DR, diabetic retinopathy
- PDR, proliferative diabetic retinopathy
- RAS, renin-angiotensin system
- antibody activating direct prorenin assay
- diabetes
- diabetic retinopathy
- prorenin
- renin-angiotensin system
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Footnotes
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The authors have no proprietary interest in any aspect of this report.