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Melanocytic intraocular tumours can grow as to exceed their vascular supply, become necrotic, and induce inflammation. They present with atypical signs and become a diagnostic challenge. We present a case of a large melanocytic intraocular tumour that offered an atypical presentation, unexpected cytology, and finally diagnostic histopathology.
A 37 year old white woman presented with a painful right eye and vision loss. Exam ination showed no light perception, a relative afferent pupillary defect, a shallow anterior chamber, and an intraocular pressure of 58 mm Hg. Dense vitreous haemorrhage and tumour obscured her fundus.
Three dimensional ultrasonography revealed vitreous haemorrhage, a total retinal detachment, and a large choroidal mass (fig 1A, B). Computed tomography and magnetic resonance imaging (MRI) of the orbits showed a 2 cm intraocular mass with a collar-button extension (arrow) consistent with a choroidal melanoma (fig 1C).
The patient participated in a discussion of the risks and benefits of treatment, found primary enucleation unacceptable, and preferred fine needle aspiration biopsy (FNAB) before treatment.
Transvitreal FNAB showed small, well preserved, spindle-shaped, dendritic, and epithelioid cells with evenly distributed melanin pigmentation (fig 2A) and no evidence of malignancy. Both cytology and subsequent immunohistochemistry were consistent with melanocytoma.
Though a combination of topical glaucoma medications and oral prednisone decreased her ocular pain, the patient consented to enucleation.
A large evenly pigmented choroidal mass measuring 12 mm in height and 17×18 mm in greatest dimension was noted. The tumour extended from the ciliary body to the optic disc.
Extensive infarction of the tumour was present. The cell outlines revealed a tumour composed of uniform large and heavily pigmented cells with round, small central nuclei. Many of these cells were magnocellular and histopathologically consistent with melanocytoma. However, distinct cells with larger nuclei and prominent nucleoli were present singly and in small clusters. In these areas, rare atypical mitoses were noted. These features were diagnostic of malignant transformation of a large melanocytoma (fig 2B). At 6 months post-enucleation there is no evidence of metastatic disease.
Melanocytomas are darkly pigmented tumours that commonly arise at the optic nerve margin. They also occur in the iris, ciliary body, and the choroid. Though largely benign and stationary, melanocytomas can (albeit rarely) undergo malignant transformation.1–8 When this occurs, it can be difficult to differentiate between melanocytomas and malignant melanomas by ultrasonography or fluorescein angiography. Adenoma and adenocarcinoma of the retinal pigment epithelium should also be considered.
In this case, FNAB did not establish the diagnosis of a malignant melanocytoma and clearly demonstrates the potential danger of relying on FNAB (alone) for the diagnosis in atypical and necrotic intraocular tumours. Foci of malignant change were missed, leading to the diagnosis of melanocytoma. Fortunately, enucleation was performed.
This case also demonstrates that melanocytomas can undergo necrosis resulting in atypical features such as opaque media, pain and inflammation. They can induce vaso-occlusive disease within the optic nerve, ischaemic necrosis of the tumour, ischaemic retinopathy, neovascular glaucoma, and melanocytic glaucoma.9 Since both necrotic melanocytomas and necrotic malignant uveal melanomas can present with the same acute symptoms (pain, inflammation, and an elevated intraocular pressure), these findings can detract the clinician’s ability to differentiate between these tumours.
Malignant change in a melanocytoma is a rare event. It is actually more common for a uveal melanoma to undergo spontaneous necrosis and present with intraocular inflammation, haemorrhage, secondary neovascularisation, and orbital inflammation. Such necrotising tumours have an increased incidence of penetration through the Bruch’s membrane, scleral invasion, and extrascleral extension.10 Clearly, large necrotic intraocular tumours can be a diagnostic challenge for both clinician and pathologist.
This work is supported by The Eye Care Foundation, Inc, and Research to Prevent Blindness, New York City, NY, USA.
The authors have no proprietary interest in the products mentioned in this study.