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Br J Ophthalmol 89:1097-1099 doi:10.1136/bjo.2005.068981
  • Clinical science
    • Scientific reports

Topical ocular antibiotics induce bacterial resistance at extraocular sites

Table 1

 Distribution of antibiotic resistance in nasopharyngeal S pneumoniae in each of the three study areas

Tetracycline treated (n = 143) Azithromycin treated (n = 194) Untreated (n = 107)
*All azithromycin resistant isolates were also resistant to tetracycline.
MIC standard values for resistance (as per NCCLS) shown in parentheses.
S pneumoniae carriage, (%) 126 (88%) 163 (84%) 91 (85%)
Antibiotic resistant S pneumoniae (% of isolates showing resistance)
    Tetracycline (⩾8 μg/ml) 39 (31%) 28 (17%) 15 (16%)
    Azithromycin* (⩾2 μg/ml) 0 (0%) 5 (3%) 0 (0%)
    Trimethoprim-sulfamethoxazole (⩾4 & 76 μg/ml) 36 (29%) 39 (24%) 25 (27%)
    Penicillin (⩾2 μg/ml) 0 (0%) 0 (0%) 0 (0%)

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