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Br J Ophthalmol 89:1134-1138 doi:10.1136/bjo.2005.070508
  • Clinical science
    • Extended reports

Corticosteroid treatment of periorbital haemangioma of infancy: a review of the evidence

Table 3

 Steroid dosage and refractive error

Author, year Subjects (total) Modality: dose* Refraction before treatment SE before treatment Refraction after treatment SE after treatment Age (months) Following (months)
*Dosages for combination steroid injections are listed as triamcinolone (mg) followed by betamethasone (mg) unless otherwise specified.
SE, spherical equivalent; Top  =  topical, IL  =  intralesional. Values in bold are for the unaffected eye, when available.
Elsas15 1994 5 (5) Top: clobetasol 0.05% +2.00+3.00×140 +3.50 +5.00+1.00×20 +5.50 14 weeks 60
+2.00 sph +2.00 +0.75 sph +0.75
Top: clobetasol 0.05% −1.50+1.00×45 −1.00 +1.50+0.50×120 +1.75 3 37
+2.00+0.50×135 +2.25 20/30
Top: clobetasol 0.05% +1.00 sph +1.00 −5.75+3.00×55 −4.25 11 weeks 38
+1.00 sph +0.75+0.75×45 +1.13
Top: clobetasol 0.05%, pred drops +1.00 sph +1.00 −10.00 −10.00 9 weeks 20
+1.00 sph +1.00 −1.00 sph −1.00
Top: clobetasol 0.05%, pred drops −1.50+1.00×135 −1.00 −1.50+1.50×145 −0.75 11 weeks 8
−1.00+0.50×90 −0.75 +1.00 sph +1.00
Kushner33 1982 5 (10) IL:l 12 mg/80 mg, 9 mg/6 mg +1.75+1.00×180 +2.25 +1.75 sph +1.75 4 7
+1.00 sph +1.00 +1.50 sph +1.50
IL: 40 mg/6 mg ×2 Plano+3.50×20 +1.75 −1.50+1.50×80 −0.75 3 13
+2.50+0.50×135 +2.75 Plano Plano
IL: 40 mg/6 mg ×2 +4.00+3.00×10 +5.50 +0.50+1.00×35 +1.00 2 13
+3.00 sph +3.00 +0.50 sph +0.50
IL: 40 mg/6 mg ×2 +1.00+2.50×80 +2.25 +0.50+0.75×80 +0.87 10 6
+0.50 sph +0.50 +0.50 sph +0.50
IL: 6 mg betamethasone +1.50 sph +1.50 +1.50 sph +1.50 3 48
+1.50 sph +1.50 +1.50 sph +1.50
Morrell19 1991 13 (15) IL: 20–40 mg/4 mg, up to 4× −1.00+3.00×110 +0.50 +1.50 sph +1.50 6 6
+3.50+1.50×155 +4.25 +2.00 sph +2.00 15 46
−0.25+0.75×180 +0.13 −0.75+0.50×180 −0.50 3 18
−0.50+2.00×180 +0.50 Plano+1.50×180 +0.75 3 12
−2.00+2.50×120 −0.75 −0.75+2.25×120 +0.38 12 21
+1.50+2.50×125 +2.75 +0.75 sph +0.75 5 24
−2.00+3.25×120 −0.38 −2.00+3.25×117 −0.38 14 years 31
+1.50+2.50×125 +2.75 +1.25+0.75×175 +1.63 5 10
+0.50+0.75×120 +0.88 +0.75 sph +0.75 6 13
+0.25+0.75×80 +0.63 Plano+0.25×80 +0.13 6 10
+5.00+2.00×90 +6.00 +3.63 16 19
+1.50+3.00×90 +3.00 +2.00+1.00×90 +2.50 5 6
+0.50+1.50×90 +1.25 +0.50+0.50×90 +0.75 6 13
Motwani32 1995 5 (23) IL: 40 mg/6 mg once +2.00+1.00×90 +2.50 +1.50 sph +1.50 4 49
+2.25+0.25×90 +2.38 +1.00 sph +1.00
+2.50+1.50×90 +3.25 +0.75+1.25×90 +1.38 3 40
+3.00+0.50×180 +3.25 +0.50+0.50×90 +0.75
−2.75+5.50×10 0.00 −3.75+3.00×10 −2.25 1.5 65
+1.00+1.75×20 +1.88 −0.50+0.75×160 −0.13
+0.75+0.50×90 +1.00 +1.00+1.00×90 +1.50 2 32
+0.75 sph +0.75 +2.00 sph +2.00
+1.00+5.00×135 +3.50 +1.50+2.00×135 +2.50 9 78
+2.50 sph +2.50

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