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Br J Ophthalmol 89:1205-1209 doi:10.1136/bjo.2005.066225
  • Laboratory science - Extended reports

Influence of format on in vitro penetration of antibody fragments through porcine cornea

Table 3

 Summary of antibody fragment penetration through perfused pig corneas (SD)

Fragment No of eyes Protein in chamber at 10 hours (µg/ml) % Penetration*
*Amount in the perfusate as percentage of the amount applied to the cornea.
ScFv 20-mer (monomer) 4 0.28 (0.20) 0.07 (0.05%)
ScFv 20-mer (dimer) 5 0.37 (0.26) 0.12 (0.09%)
ScFv 11-mer (dimer) 4 0.27 (0.24) 0.08 (0.07%)
Fab (monomer) 5 0.23 (0.18) 0.013 (0.008%)

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