rss
Br J Ophthalmol 2006;90:1366-1369 doi:10.1136/bjo.2006.094912
  • Clinical science
    • Extended reports

Trefoil factor family 1, MUC5AC and human leucocyte antigen-DR expression by conjunctival cells in patients with glaucoma treated with chronic drugs: could these markers predict the success of glaucoma surgery?

  1. M Souchier1,
  2. N Buron2,
  3. P O Lafontaine1,
  4. A M Bron1,
  5. C Baudouin3,
  6. C Creuzot-Garcher1
  1. 1Department of Ophthalmology, University Hospital, Dijon, France
  2. 2INSERM U 517, University Hospital
  3. 3Centre Hospitalier National d’Ophtalmologie des Quinze Vingts, Paris, France
  1. Correspondence to: A M Bron Service d’Ophtalmologie, Hôpital Général, 21000 Dijon, France;alain.bron{at}chu-dijon.fr
  • Accepted 16 May 2006
  • Published Online First 29 June 2006

Abstract

Aims: To evaluate conjunctival expression of trefoil factor family (TFF)1, MUC5AC and human leucocyte antigen (HLA)-DR in patients with glaucoma treated with topical drugs, and to determine whether these parameters can predict the outcome of glaucoma surgery.

Methods: 77 conjunctival impression cytology specimens were collected from 77 patients with glaucoma (66 receiving drops with preservative and 11 treated with preservative-free drops) and 43 controls. TFF1, MUC5AC and HLA-DR expression was analysed using flow cytometry. Trabeculectomy was performed in 56 patients; success was defined as an intraocular pressure (IOP) ≤15 mm Hg without any IOP-lowering drug at 6 months.

Results: The expression of TFF1, MUC5AC and HLA-DR was significantly higher in patients than in controls (p = 0.01, 0.05 and 0.004, respectively). A higher expression of MUC5AC was found in patients treated with preserved drops than in those receiving unpreserved drops (p = 0.04). A higher MUC5AC expression and a lower HLA-DR expression was observed in successful glaucoma surgeries than in failures.

Conclusions: TFF1 and MUC5AC secretions are probably a response to mild ocular surface changes caused by long-term use of topical treatment. Their increased expression could be a predicting factor of further successful glaucoma surgery.

Footnotes

  • Published Online First 29 June 2006

  • Competing interests: None.

  • This work has been partly presented as a poster at the ARVO meeting, 2005.

    Ethical approval: The protocol of this prospective, observational, case–control study was approved by the local ethics committee of the Burgundy region, located in Dijon, France.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All versions of this article:
    1. bjo.2006.094912v1
    2. 90/11/1366 most recent

Responses

  1. Submit a response
  2. No responses published

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.