Article Text

Structural and functional assessment of the macular region in patients with glaucoma
  1. F N Kanadani1,
  2. D C Hood2,
  3. T M Grippo1,
  4. B Wangsupadilok1,
  5. N Harizman1,
  6. V C Greenstein4,
  7. J M Liebmann3,
  8. R Ritch1,5
  1. 1Departments of Ophthalmology, The New York Eye and Ear Infirmary, New York, New York, USA
  2. 2Department of Psychology, Columbia University, New York
  3. 3Manhattan Eye, Ear & Throat Hospital, New York
  4. 4New York University Medical Center, New York
  5. 5New York Medical College, Valhalla, New York
  1. Correspondence to: D C Hood Department of Psychology, Columbia University, 405 Schermerhorn, New York, NY 10027, USA; dch3{at}


Purpose: To investigate the correlation of a structural measure of the macular area (optical coherence tomography (OCT)) with two functional measures (10-2 Humphrey visual field (HVF) and multifocal visual evoked potential (mfVEP)) of macular function.

Methods: 55 eyes with open-angle glaucoma were enrolled. The 10-2 HVF was defined as abnormal if clusters of ⩾3 points with p<5%, one of which had p<1%, were present. The mfVEP was abnormal if probability plots had ⩾2 adjacent points with p<1%, or ⩾3 adjacent points with p<5% and at least one of these points with p<1%. Two criteria were used for the macular OCT: (I) ⩾2 sectors with p<5% or 1 sector with p<1% and (II) 1 sector with p<5%.

Results: 54 of the 55 eyes showed an abnormal 10-2 HVF and 50 had central mfVEP defects. The two OCT criteria resulted in sensitivities of 85% and 91%. When both functional tests showed a defect (in 49 eyes), the OCT was abnormal in 45. For the OCT the outer and inner inferior regions were the most likely to be abnormal, and both functional techniques were most abnormal in the superior hemifield.

Conclusions: Good agreement exists between macular thickness and functional defects in patients with glaucoma. Study of the macular region may provide a quantitative measure for disease staging and monitoring.

  • HVF, Humphrey visual field
  • mfVEP, multifocal visual evoked potential
  • NFL, nerve fibre layer
  • OCT, optical coherence tomography
  • RGC, retinal ganglion cells
  • RNFL, retinal nerve fibre layer

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  • Published Online First 9 August 2006

  • Competing interests: None.

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