Article Text

PDF
Retrobulbar haemodynamics and morphometric optic disc analysis in primary open-angle glaucoma
  1. N Plange1,
  2. M Kaup1,
  3. A Weber1,
  4. K O Arend2,
  5. A Remky1
  1. 1Department of Ophthalmology, RWTH Aachen University, Aachen, Germany
  2. 2Eye Center Alsdorf, Alsdorf, Germany
  1. Correspondence to: N Plange Department of Ophthalmology, RWTH Aachen University, Pauwelsstr 30, 52057 Aachen, Germany; nplange{at}ukaachen.de

Abstract

Background: Previous studies confirmed reduced retrobulbar haemodynamics in primary open-angle glaucoma (POAG).

Aim: To investigate a correlation between retrobulbar haemodynamics and morphometric neuroretinal rim analysis in patients with POAG.

Methods: 51 patients with POAG (mean (standard deviation (SD)) age 65 (11) years) were included in this clinical study. Blood flow velocities (peak systolic velocity (PSV) and end-diastolic velocity (EDV)) of the ophthalmic artery, central retinal artery (CRA), posterior ciliary arteries (PCA) and central retinal vein were measured using colour Doppler imaging (Siemens Sonoline Sienna, Erlangen, Germany). Optic disc morphometry was carried out using scanning laser tomography (Heidelberg Retinal Tomograph II Heidelberg Egineering Heidelberg, Germany). The stereometric parameters of the neuroretinal rim (rim area, rim volume, cup shape measure and retinal nerve fibre layer (RNFL) cross-sectional area) were used for analysis.

Results: The PSV of the CRA was significantly (p<0.001) correlated with rim area (r = 0.50) and rim volume (r = 0.51). The minimum velocities of the central retinal vein were significantly (p<0.001) correlated with rim volume (r = 0.56) and RNFL cross-sectional area (r = 0.49). No correlations were found for the flow velocities of the ophthalmic artery and PCAs.

Conclusion: Retrobulbar haemodynamics of the central retinal artery and vein are correlated with the neuroretinal rim damage in POAG.

  • CDI, colour Doppler imaging
  • CPSD, corrected pattern standard deviation
  • CRA, central retinal artery
  • EDV, end-diastolic velocity
  • IOP, intraocular pressure
  • PCA, posterior ciliary arteries
  • POAG, primary open-angle glaucoma
  • PSV, peak systolic velocity
  • RNFL, retinal nerve fibre layer

Statistics from Altmetric.com

Footnotes

  • Funding: None.

  • Competing interests: None.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.