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Epstein-Barr virus infected cells in the aqueous humour originated from nasal NK/T cell lymphoma
  1. S Kase,
  2. K Namba,
  3. N Kitaichi,
  4. S Ohno
  1. Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan
  1. Correspondence to: Satoru Kase MD, PhD, Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638 Japan; kaseron{at}med.hokudai.ac.jp

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Nasal natural killer (NK)/T cell lymphoma is a definitive diagnostic entity in the World Health Organization lymphoma classification.1 In many cases, NK/T cell lymphoma is invariably associated with Epstein-Barr virus (EBV). Although ocular involvement is found in less than 10% of patients with systemic lymphoma,2 because of its anatomical proximity, nasal NK/T lymphoma can sometimes complicate uveitis and orbital infiltration.3 We experienced a case of nasal NK/T lymphoma, and the cells collected from the aqueous humour originated from the lymphoma which was infected by EBV.

Case report

A 53 year old man noticed nasal obstruction and imaging demonstrated a mass lesion in the nasal cavity. The biopsy specimen from the cavity demonstrated a variety of diffuse atypical lymphoid cell infiltration. Immunohistochemically, the atypical cells showed cytoplasmic reactivity for CD56, CD3, granzyme B and perforin, but not for CD20. Many EBV encoded small RNA (EBER) positive cells were detected in the lymphoma tissues. The …

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