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Br J Ophthalmol 2006;90:383-388 doi:10.1136/bjo.2005.079905
  • Perspective

Mechanosensitivity and the eye: cells coping with the pressure

  1. J C H Tan1,2,
  2. F B Kalapesi1,
  3. M T Coroneo1
  1. 1Department of Ophthalmology, Prince of Wales Hospital, University of New South Wales, Sydney, Australia
  2. 2Department of Ophthalmology and Visual Science, University of Wisconsin-Madison, WI, USA
  1. Correspondence to: Professor Minas T Coroneo Department of Ophthalmology, Prince of Wales Hospital, High Street, Randwick, NSW 2032, Australia; m.coroneo{at}unsw.edu.au
  • Accepted 1 November 2005

Abstract

The cells of the various organ systems in humans are subject to mechanical forces to which they must respond. Here the authors review what is known of the ways in which the cells of animals, ranging from the prokaryotic to humans, sense and transduce mechanical forces to respond to such stimuli. In what way this pertains to the eye, especially with respect to axial myopia and the pressure related disease of glaucoma, is then surveyed.

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