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Br J Ophthalmol 2006;90:516 doi:10.1136/bjo.2005.085837
  • Letter

Dapsone induced haemolytic anaemia in patients treated for ocular cicatricial pemphigoid

  1. M S Wertheim,
  2. J J Males,
  3. S D Cook,
  4. D M Tole
  1. Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
  1. Correspondence to: Michael S Wertheim Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK; drwertie{at}hotmail.com
  • Accepted 3 December 2005

Ocular cicatricial pemphigoid (OCP) is a systemic autoimmune disease of unknown aetiology. It causes a chronic, scarring conjunctivitis and frequently affects other mucous membranes. Definitive diagnosis is made by immunofluorescent staining of conjunctival tissue demonstrating IgG, IgM, and or IgA in the basement membrane.1 Dapsone is an immunomodulating sulphonamide and has widely been used in the treatment of mild to moderate OCP.2–4 All patients treated with dapsone show varying …

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