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HLA typing of a Hong Kong Chinese family with intermediate uveitis
  1. A C Browning1,
  2. D Calladine1,
  3. N Collins2,
  4. A W Harmer2,
  5. W M Amoaku3
  1. 1Division of Ophthalmology and Visual Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK
  2. 2National Blood Service, Longley Lane, Sheffield S5 7JN, UK
  3. 3Division of Ophthalmology and Visual Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK
  1. Correspondence to: Winfried M Amoaku Division of Ophthalmology and Visual Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham NG7 2UH, UK; wma{at}nottingham.ac.uk

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Intermediate uveitis (IU) is a potentially sight threatening condition seen in all racial groups. While the disorder is known to be associated with a number of systemic conditions, in the majority of cases, no underlying cause is found. Because autoimmunity may play a part in the pathogenesis of the disease, workers have studied the immunogenetics of non-familial IU and have suggested a role for certain HLA alleles such as HLA-A*28 HLA-DRB1*15, HLA-B*51, and B*08 in promoting susceptibility to the condition in predominantly white populations.1–5

While IU is a relatively common diagnosis in a uveitis clinic, constituting up to 15% of all uveitis cases seen,6 there are few reports in the literature of familial cases. In this study, a Hong Kong Chinese family was identified, some members of who …

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