Article Text

PDF
Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea
  1. K Palombi1,
  2. E Renard1,
  3. P Levy2,3,
  4. C Chiquet1,
  5. Ch Deschaux2,3,
  6. J P Romanet1,
  7. J L Pépin2,3
  1. 1Department of Ophthalmology, University Hospital, Grenoble, France
  2. 2Sleep Laboratory and EFCR, University Hospital, Grenoble, France
  3. 3HP2 Laboratory, INSERM ERI 0017 (Hypoxia: Pathophysiology), Joseph Fourier University, Grenoble, France
  1. Correspondence to: Jean-Louis Pépin Laboratoire du sommeil, EFCR, CHU de Grenoble, BP 217X, 38043, Grenoble Cedex 09, France; jpepin{at}chu-grenoble.fr

Abstract

Aim: To evaluate newly diagnosed non-arteritic anterior ischaemic optic neuropathy (NAION) patients for the existence of an associated sleep apnoea syndrome.

Methods: Newly identified NAION patient underwent polysomnography. The prevalence of sleep apnoea in NAION patients was compared to the prevalence previously found in the general population. Hypertension, diabetes, hyperlipidaemia, and atheromatous lesions of carotid vessels as classic risk factors associated with NAION were also identified.

Results: 27 consecutive newly diagnosed NAION patients (18 men and nine women, mean age 65 (SD 8) years, body mass index 27.2 (3.8) kg/m2) were included in the study. 24 of these 27 NAION patients (89%) exhibited a sleep apnoea syndrome (respiratory disturbance index: 37.2/h (SD 18.3/h). Risk ratio for a NAION patient to have sleep apnoea was 4.9 compared to the general population (p<0.001). Sleep apnoea was 1.5–2-fold more frequent than the rate of the other identified risk factors typically associated with NAION (hypertension, diabetes).

Conclusions: Sleep apnoea is the most frequent disorder associated with NAION and should be screened in this population. At least a questionnaire related to obstructive sleep apnoea symptoms and assessment of sleepiness should be systematically proposed to patients with NAION.

  • BMI, body mass index
  • FN, false negative
  • FP, false positive
  • NAION, non-arteritic anterior ischaemic optic neuropathy
  • OSA, obstructive sleep apnoea
  • RDI, respiratory disturbance index
  • RR, risk ratio
  • TST, total sleep time
  • non-arteritic anterior ischaemic optic neuropathy
  • sleep apnoea
  • positive airway pressure
  • risk factors
  • BMI, body mass index
  • FN, false negative
  • FP, false positive
  • NAION, non-arteritic anterior ischaemic optic neuropathy
  • OSA, obstructive sleep apnoea
  • RDI, respiratory disturbance index
  • RR, risk ratio
  • TST, total sleep time
  • non-arteritic anterior ischaemic optic neuropathy
  • sleep apnoea
  • positive airway pressure
  • risk factors

Statistics from Altmetric.com

Footnotes

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles

    • BJO at a glance
      Creig Hoyt