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Occult retinal and choroidal lesions in neurofibromatosis type 1
  1. S Ishiko,
  2. A Yoshida,
  3. Y Kato,
  4. H Kagokawa
  1. Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan
  1. Correspondence to: Satoshi Ishiko MD, Department of Ophthalmology, Asahikawa Medical College, 2-1 Midorigaoka Higashi, Asahikawa, 078-8510 Japan; ishiko{at}asahikawa-med.ac.jp

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Neurofibromatosis 1, a common inherited disorder,1 is considered a neurocristopathy characterised by pathological hamartomatous proliferations of neural crest derived tissues.1,2 Neurofibromatosis can be observed in any tissue with neural crest cells throughout the body, including the eye. However, retinal and choroidal lesions had been considered unusual in eyes with this disease,3 although Lisch nodules are frequently observed.4 Because choroidal abnormalities especially have been reported in up to 100% of cases during examinations using infrared monochromatic light and the confocal scanning laser ophthalmoscope (SLO),5 choroidal involvement is thought to be common in neurofibromatous 1.

Conventional optical coherence tomography (OCT) can non-invasively obtain optical cross sectional retinal images with histological detail.6 Newly developed three dimensional (3-D) OCT operates in a so called transverse fashion and yields OCT images originating at the same axis and plane as the retina.7,8 Because this instrument simultaneously produces SLO and interferometric OCT images, it readily allows detection of an area of pathology in …

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