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Br J Ophthalmol 2006;90:964-967 doi:10.1136/bjo.2006.092528
  • Clinical science
    • Scientific reports

Development of ocular disease in patients with mucous membrane pemphigoid involving the oral mucosa

  1. G T Higgins1,
  2. R B Allan2,
  3. R Hall2,
  4. E A Field2,
  5. S B Kaye1
  1. 1St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
  2. 2Department of Oral Medicine, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
  1. Correspondence to: MrGareth Higgins MD, St Paul’s Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK; chanhiggins{at}tiscali.co.uk
  • Accepted 30 March 2006
  • Published Online First 13 April 2006

Abstract

Aim: To determine the rate of development of ocular disease in patients presenting with mucous membrane pemphigoid (MMP) involving their oral mucosa.

Methods: Diagnosis of oral MMP was made on the basis of clinical signs, histology, and direct and indirect immunofluorescence. Age, race, sex, age at diagnosis, progression of eye signs, duration of follow up, and time to progression of ocular disease were recorded.

Results: 30 patients with established oral MMP were reviewed. The mean age at diagnosis was 65.2 years (range 46–84 years) and 16/30 (53%) were male. At initial ocular review nine (30%) patients showed ocular signs of pemphigoid, of whom two had mild (IIA IIIB), four moderate (IIB IIIC), and three severe (IIC IIID) disease. The mean interval between diagnosis of oral MMP and first ophthalmic review was 19.3 months (range 0–144). Over the period of follow up two (7%) patients developed ocular disease at 19 months and 48 months, respectively, despite having had no evidence of ocular involvement at presentation. In total, 11 (37%) patients with oral disease eventually showed ocular disease with a calculated incidence rate for the development of ocular disease of 0.03 per person year over 5 years.

Conclusions: MMP may affect different tissues at different stages, often separated by many years. Patients with MMP involving their oral mucosa are at significant risk of developing ocular disease and should remain under ophthalmic review.

Footnotes

  • Commercial relationship: none.

  • As this work was performed as an audit, ethical approval was not required.

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