Intraocular soluble IL-2 receptor alpha in a patient with adult T cell leukaemia with intraocular invasion
- S Sugita1,
- H Takase1,
- T Yoshida1,
- Y Sugamoto1,
- T Watanabe2,
- M Mochizuki3
- 1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
- 2Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
- 3Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, Tokyo, Japan
- Correspondence to: Dr S Sugita Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University Graduate School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan; sunaoph{at}tmd.ac.jp
- Accepted 18 March 2006
It has been reported that human T cell lymphotropic virus type I (HTLV-I) infection is related to a wide range of ocular disorders, such as intraocular lymphoma,1,2 uveitis,3 and cytomegalovirus (CNV) retinitis.4 The diagnosis of adult T cell leukaemia (ATL) cell infiltration in the eye is often difficult, even when characteristic ocular findings are present and cytological examinations of intraocular fluids are performed. It is well known that determination of patient serum interleukin 2 receptor alpha (sIL-2Rα) levels is critical in the evaluation of the clinical status of the disease.5 We report here a patient with systemic ATL who developed vitreous opacities and subretinal lesions and in whom vitreous measurement of the soluble form of sIL-2Rα provided information that could be used in making a diagnosis and in treating associated ocular disorders.
Case report
A 69 year old man with a 2 year history of systemic ATL developed a sudden onset of decreased vision and vitreous floaters in the left eye. Funduscopic examination of the left eye revealed dense vitreous opacities and whitish retinal exudates along with superior vascular arcade (fig 1A). Based on the ocular manifestations and …
