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Increased expression of mucinous glycoprotein KL-6 in human pterygium
  1. S Kase,
  2. N Kitaichi,
  3. N Furudate,
  4. K Yoshida,
  5. S Ohno
  1. Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan
  1. Correspondence to: Satoru Kase MD, PhD, Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, Sapporo 060-8638, Japan; kaseron{at}med.hokudai.ac.jp

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Pterygia represent growth onto the cornea of fibrovascular tissue continuous with the conjunctiva.1 KL-6 (Krebs von den Lunge-6) is a high molecular weight mucinous glycoprotein, and the monoclonal antibody reacts with the sugar moiety of MUC-1.2,3 We have reported that measurement of serum KL-6 levels is useful for the diagnosis and management of uveitis patients with sarcoidosis.4,5 The aim of this study was to examine the expression of KL-6, and Ki-67, a proliferation marker, in normal human conjunctiva, pterygium, and pseudopterygium tissues.

Methods

Five samples consisting of one normal conjunctiva, three pterygia, and one pseudopterygium were surgically collected. Formalin fixed and paraffin embedded tissue sections were incubated with anti-KL-6 and anti-Ki-67 monoclonal antibodies, and then examined immunohistochemically.

Results

Immunoreactivity for KL-6 was detected on the apical membrane of the wing and basal …

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