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Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography
  1. Haitao Li1,
  2. Christopher Kai Shun Leung1,2,
  3. Carol Yim Lui Cheung1,
  4. Lee Wong1,
  5. Chi Pui Pang1,
  6. Robert Neal Weinreb2,
  7. Dennis Shun Chiu Lam1
  1. 1
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong
  2. 2
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, USA
  1. Dr Christopher Kai Shun Leung, Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong; tlims00{at}hotmail.com

Abstract

Aim: To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography.

Methods: Twenty-five normal subjects were invited for anterior chamber angle imaging with an anterior segment optical coherence tomography (OCT) on one randomly selected eye in three separate visits within a week. Each eye was imaged three times under room light (light intensity = 368 lux) and three times in the dark during the first visit. In the subsequent visits, each eye was imaged once in the light and once in the dark. The angle opening distance (AOD 500) and the trabecular–iris angle (TIA 500) were measured by a single observer. Only the nasal angle was analysed. Intrasession and intersession within-subject standard deviation (Sw), precision (1.96×Sw), coefficient of variation (CVw) (100×Sw/overall mean), and intraclass correlation coefficient (ICC) were calculated to evaluate repeatability and reproducibility.

Results: For intrasession repeatability, the Sw, precision, CVw and ICC of AOD/TIA were 45 μm/2.4°, 88 μm/4.7°, 5.8%/4.8% and 0.97/0.95 in the light; and 45 μm/2.1°, 88 μm/4.2°, 7.0%/5.0% and 0.98/0.97 in the dark. For intersession reproducibility, the Sw, precision, CVw and ICC of AOD/TIA were 79 μm/3.5°, 155 μm/6.8°, 10.0%/7.0%, 0.91/0.89 in the light; and 64 μm/3.4°, 124 μm/6.6°, 9.9%/7.8% and 0.95/0.92 in the dark.

Conclusions: The anterior segment OCT demonstrated reliable anterior chamber angle measurement in different lighting conditions with good repeatability and reproducibility.

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Footnotes

  • Competing interests: None declared.

  • Funding: CL has received an honorarium from Carl Zeiss Meditec for a conference presentation. RW has received research support in the form of instruments from Carl Zeiss Meditec. He has also been a consultant for Carl Zeiss Meditec.

  • Abbreviations:
    AOD

    angle opening distance

    CVw

    coefficient of variation

    ICC

    intraclass correlation coefficient

    OCT

    optical coherence tomography

    Sw

    within-subject standard deviation

    TIA

    trabecular–iris angle

    UBM

    ultrasound biomicroscopy

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