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Br J Ophthalmol 2007;91:1563-1564 doi:10.1136/bjo.2007.115626
  • Letter

Rituximab for the treatment of extranodal marginal zone B-cell lymphoma of the lacrimal gland

  1. Carsten Heinz1,
  2. Hartmut Merz2,
  3. Matthias Nieschalk3,
  4. Heribert Mueller-Miny4,
  5. Peter Koch5,
  6. Arnd Heiligenhaus6
  1. 1
    Department of Ophthalmology, St. Franziskus-Hospital Muenster, Muenster, Germany and Department of Ophthalmology, University of Duisburg-Essen, Duisburg, Germany
  2. 2
    Department of Pathology, University of Schleswig-Holstein, Luebeck, Germany
  3. 3
    Department of ENT, St. Franziskus-Hospital Muenster, Muenster, Germany
  4. 4
    Department of Radiology, St. Franziskus-Hospital Muenster, Muenster, Germany
  5. 5
    Department of Medicine Haematology/Oncology, University of Muenster, Muenster, Germany
  6. 6
    Department of Ophthalmology, St. Franziskus-Hospital Muenster, Muenster, Germany and Department of Ophthalmology, University of Duisburg-Essen, Duisburg, Germany
  1. Dr Carsten Heinz, Department of Ophthalmology, St. Franziskus-Hospital Muenster, Hohenzollernring 54, 48145 Muenster, Germany; carsten.heinz{at}uveitis-zentrum.de
  • Accepted 30 January 2007

Extranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) of the lacrimal gland is a rare condition. Treatment options chiefly include radiation of the tumour, chemotherapy, surgical removal or a combination of these strategies.1 Radiation therapy is associated with a high risk of ocular morbidity, especially dry eye.1 Here, we report a case of a biopsy-proven extranodal MALT lymphoma of the lacrimal gland treated with two courses of four weekly cycles of rituximab.

Case report

A 64-year-old woman presented with unilateral ptosis and swelling of her right lacrimal gland. Best-corrected visual acuity was 20/25. Slit-lamp examination showed severe punctate superficial keratopathy (basal secretion 0 mm OU). …

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