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Expression of hypoxia-inducible factor 1α and 2α in choroidal neovascular membranes associated with age-related macular degeneration
  1. Yuji Inoue,
  2. Yasuo Yanagi,
  3. Kyosuke Matsuura,
  4. Hidenori Takahashi,
  5. Yasuhiro Tamaki,
  6. Makoto Araie
  1. Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
  1. Yuji Inoue or Yasuo Yanagi, Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; yino-tky{at}umin.ac.jp or yanagi-tky{at}umin.ac.jp

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Hypoxia-inducible factors (HIF-1α and HIF-2α) play pivotal roles in angiogenesis. However, their involvement in choroidal neovascular membranes (CNVMs) is still unknown. This study investigates the distribution of HIF-1α and HIF-2α proteins in six CNVMs associated with age-related macular degeneration (AMD). By means of immunohistochemical analysis, HIF-1α and HIF-2α were detected in 5 and 6 eyes, respectively. Endothelial cells and macrophages were immunostained by both HIF-1α and HIF-2α antibodies, whereas no staining was observed in retinal pigment epithelial (RPE) cells. Our study raises the possibility that HIF-1α and HIF-2α are involved in CNV formation.

HIF-1α and HIF-2α are transcription factors that transactivate the expression of pro-angiogenic genes in response to hypoxic conditions, and play important roles in vasculogenesis …

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