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Hypoxia-inducible factors (HIF-1α and HIF-2α) play pivotal roles in angiogenesis. However, their involvement in choroidal neovascular membranes (CNVMs) is still unknown. This study investigates the distribution of HIF-1α and HIF-2α proteins in six CNVMs associated with age-related macular degeneration (AMD). By means of immunohistochemical analysis, HIF-1α and HIF-2α were detected in 5 and 6 eyes, respectively. Endothelial cells and macrophages were immunostained by both HIF-1α and HIF-2α antibodies, whereas no staining was observed in retinal pigment epithelial (RPE) cells. Our study raises the possibility that HIF-1α and HIF-2α are involved in CNV formation.
HIF-1α and HIF-2α are transcription factors that transactivate the expression of pro-angiogenic genes in response to hypoxic conditions, and play important roles in vasculogenesis …
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