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Br J Ophthalmol 2007;91:1726-1727 doi:10.1136/bjo.2007.116681
  • Letter
    • PostScript

Unilateral diffuse uveal melanocytic proliferation (DUMP)

  1. Shantan Reddy1,
  2. Paul T Finger2
  1. 1
    The New York Eye Cancer Center and New York University School of Medicine, New York City, NY, USA
  2. 2
    The New York Eye Cancer Center and New York University School of Medicine, New York City, NY, USA
  1. Dr Paul T Finger, Director, The New York Eye Cancer Center, 115 East 61st Street, New York, NY 10065, USA; pfinger{at}eyecancer.com
  • Accepted 3 March 2007

Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic syndrome first described by Machemer 40 years ago in a patient with pancreatic carcinoma.1 Gass and associates later expanded the syndrome to include round red patches in the fundus, multifocal areas of retinal pigment epithelial (RPE) atrophy, rapidly progressive cataracts, retinal detachments, and choroidal thickening.2 There have been 34 reported cases since Machemer first described it, and all have had bilateral involvement.3–8 After searching databases such as MEDLINE (1947 to the present), Exerpta Medica/EMBASE (1947 to the present), and Ophthalmic Literature (1947 to 1988) using the key words BDUMP, melanocytic proliferation, paraneoplastic, and uvea, we report the first case—to the best of …

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