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Possible association between scleritis and lymphoma
  1. Lynnelle K Smith1,
  2. Eric B Suhler2,
  3. Lyndell L Lim3,
  4. Dongseok Choi4,
  5. George A Cioffi5,
  6. James T Rosenbaum6
  1. 1
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA
  2. 2
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA and Portland VA Medical Center
  3. 3
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA and University of Melbourne, Melbourne, Australia
  4. 4
    Department of Public Health and Preventive Medicine, Oregon Health & Science University, Portland, Oregon, USA
  5. 5
    Devers Eye Institute, Legacy Good Samaritan Hospital, Portland, Oregon, USA
  6. 6
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA
  1. Dr James T Rosenbaum, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, Oregon 97239-4197; rosenbaj{at}ohsu.edu

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Scleritis and uveitis are ocular inflammatory diseases often presumed to be autoimmune and associated with underlying systemic disease.1 Other autoimmune diseases have been shown to confer increased risk for malignancy, including lymphoma.24 We present two patients diagnosed with scleritis and lymphoma and examine whether there is an association between ocular inflammatory disease and malignancy.

Case series

We reviewed the records of 133 scleritis patients presenting to our ocular inflammatory diseases clinic at Oregon Health & Science University (OHSU) between 1993 and 2006. Access to this database was reviewed and approved by the OHSU institutional review board. Two patients with a diagnosis of lymphoma were identified.

Patient A developed scleritis 13 years before being diagnosed with lymphoma at the age of 48. Hodgkin’s lymphoma was found incidentally on a chest x ray during repeated work up for ocular disease. Patient B was diagnosed and treated for Hodgkin’s lymphoma at the age of 24 without recurrence. She developed …

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