rss
Br J Ophthalmol 2007;91:248-252 doi:10.1136/bjo.2006.103580
  • Laboratory science - Extended reports

Comparison of acute structural and histopathological changes in human autopsy eyes after endoscopic cyclophotocoagulation and trans-scleral cyclophotocoagulation

  1. Mina B Pantcheva,
  2. Malik Y Kahook,
  3. Joel S Schuman,
  4. Robert J Noecker
  1. UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
  1. Correspondence to: Dr Mina B Pantcheva 203 Lothrop Street, Pittsburgh, PA 15213, USA; minapantcheva{at}yahoo.com
  • Accepted 8 September 2006
  • Published Online First 20 September 2006

Abstract

Aim: To study the histological effects of trans-scleral cyclophotocoagulation (TCP) and endoscopic cyclophotocoagulation (ECP) on the ciliary body and other structures collected at autopsy and to compare with untreated controls.

Materials and methods: TCP and ECP were performed on human eyes at autopsy. Detailed histological evaluations were perfomed using light microscopy and scanning electron microscopy on treated eyes and compared with untreated controls.

Results: Histological changes were observed with both light microscopy and scanning electron microscopy for all treated tissues. Tissue treated with TCP showed pronounced tissue disruption of the ciliary body muscle and stroma, ciliary processes, and both pigmented and non-pigmented ciliary epithelium. ECP-treated tissue exhibited pronounced contraction of the ciliary processes with disruption of the ciliary body epithelium, sparing of the ciliary body muscle and less architectural disorganisation. The sclera was not affected by either laser treatment.

Conclusions: ECP treatment caused less damage to the ciliary body compared with TCP when evaluated by light microscopy and scanning electron microscopy. Compared with TCP, ECP seems to be a more selective form of cyclophotocoagulation, resulting in less tissue disruption while achieving the goal of destroying ciliary body epithelium.

Footnotes

  • Funding: Core Grant for Vision Research—EY080908, supported in part by an unrestricted grant from Research to Prevent Blindness and The Eye and Ear Foundation (Pittsburgh, PA).

  • Competing interests: RJN has received honoraria for speakerships for EndoOptiks.

  • Published Online First 20 September 2006

    The authors do not have a financial/proprietary interest in any of the devices, equipment, instruments or drugs discussed in this article.

    The results of this study have been presented at the American Glaucoma Society (AGS) meeting in Charlestown, South Carolina, USA, March 2006.

  • RJNis on the Speakers Bureau for EndoOptiks.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All Versions of this Article:
    1. bjo.2006.103580v1
    2. 91/2/248 most recent

Services

  1. Email this link to a friend
  2. Alert me when this article is cited
  3. Alert me if a correction is posted
  4. Alert me when eletters are published
  5. Article Usage Statistics
  6. Similar articles in this journal
  7. Similar articles in Web of Science
  8. Similar articles in PubMed
  9. Add article to my folders
  10. Download to citation manager
  11. Request permissions

Responses

  1. Submit a response
  2. No responses published

Social bookmarking

Register for free content


Free sample
 This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
View free sample issue >>

Free archive
The full back archive is now available for BJO. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
Register to access the free archive >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.