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  • Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation

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Positive correlation between vitreous levels of advanced glycation end products and vascular endothelial growth factor in patients with diabetic retinopathy sufficiently treated with photocoagulation
  1. Masahiko Yokoi1,
  2. Sho-ichi Yamagishi2,
  3. Masayoshi Takeuchi3,
  4. Takanori Matsui4,
  5. Yumiko Yoshida4,
  6. Kazuhiro Ohgami5,
  7. Tamami Amano-Okamoto6,
  8. Shigeaki Ohno7
  1. 1Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
  2. 2Department of Internal Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan
  3. 3Department of Biochemistry, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan
  4. 4Department of Internal Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan
  5. 5Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
  6. 6Department of Ophthalmology, Nippon Telegraph and Telephon East Corporation Sapporo Hospital, Sapporo, Japan
  7. 7Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
  1. Correspondence to: Dr Masahiko Yokoi Department of Ophthalmology, Teine-Keijinkai Hospital, Maeda 1–12, Teine–ku, Sapporo 006-8555, Japan;zoyokoi.tdr{at}keijinkai.or.jp

https://doi.org/10.1136/bjo.2006.100198

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    We investigated whether vitreous levels of advanced glycation end products (AGEs) were positively correlated with vascular endothelial growth factor (VEGF) in patients with diabetic retinopathy patients sufficiently treated with retinal photocoagulation. Vitreous AGE and VEGF levels were significantly higher in patients with diabetes than in controls. Positive correlation between AGE and VEGF was found in patients with diabetic retinopathy sufficiently treated with retinal photocoagulation (r = 0.44, p<0.05), but not in those who were insufficiently treated (r = 0.26, p = 0.18). The present observations suggest that AGE may induce VEGF expression in an ischaemia-independent mechanism. AGE could be one of the important determinants of VEGF in diabetic retinopathy without obvious ischaemic regions.

    Background

    Vascular endothelial growth factor (VEGF) elicits retinal vascular hyperpermeability, thrombosis and angiogenesis, having a central role in the pathogenesis of diabetic retinopathy.1 Furthermore, vitreous VEGF levels are increased in proliferative diabetic retinopathy, whereas the levels are decreased after treatment with …

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    Footnotes

    • Funding: This work was supported in part by Grants of Venture Research and Development Centers from the Ministry of Education, Culture, Sports, Science and Technology, Japan (SY), and the Specific Research Fund of Hokuriku University, Japan (MT).

    • Competing interests: None declared.