Aim: To compare photodynamic therapy (PDT) with PDT associated with systemic steroids (SS) for the control of juxta/subfoveal idiopathic choroidal neovascularisation (ICNV).
Methods: Patients with juxta/subfoveal ICNV were randomised and then treated. Visual gain and loss were defined as improvement in or worsening for two or more lines of best-corrected visual acuity (BCVA), respectively. Choroidal neovascularisation size after treatment was classified as “increased” and “reduced” if it was increased or reduced by >200 μm2, respectively.
Results: 10 patients were treated with PDT, 10 with SS followed by PDT. The median follow-up time was 22 and 21 months for the “steroid+PDT group” and the “PDT group”, respectively. At 1 year, in the PDT group, five patients had stable/improved BCVA, and five became worse; the mean number of PDT was 2.3; in the steroid+PDT group, all patients were stable/improved and the mean number of PDT was 1.2. The difference between the two groups was significant (p<0.05). At 1 year, the ICNV size after treatment was better in the steroid+PDT group than in the PDT group (p<0.05).
Conclusion: The use of SS before PDT has shown better BCVA outcome than PDT alone (p<0.05), reducing the mean number of PDT applications (1.2 vs 2.3, respectively), with smaller scar size.
- BCVA, best-corrected visual acuity
- CNV, choroidal neovascularisation
- FA, fluorescein angiography
- ICNV, idiopathic choroidal neovascularisation
- PDT, photodynamic therapy
- SS, systemic steroids
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Published Online First 3 January 2007
Competing interests: None.