rss
Br J Ophthalmol 91:737-738 doi:10.1136/bjo.2006.109843
  • Clinical science
    • Scientific reports

Positive correlation between pigment epithelium-derived factor and monocyte chemoattractant protein-1 levels in the aqueous humour of patients with uveitis

  1. Yumiko Yoshida1,
  2. Sho-ichi Yamagishi2,
  3. Takanori Matsui2,
  4. Kazuo Nakamura2,
  5. Tsutomu Imaizumi2,
  6. Koichi Yoshimura1,
  7. Ryoji Yamakawa1
  1. 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan
  2. 2Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan
  1. Correspondence to: Dr S Yamagishi Department of Medicine, Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan; shoichi{at}med.kurume-u.ac.jp
  • Accepted 9 December 2006
  • Published Online First 13 December 2006

Abstract

Aim: To evaluate whether aqueous humour levels of pigment epithelium-derived factor (PEDF) are associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis.

Methods: Aqueous humour levels of MCP-1 and PEDF were determined by ELISA in 34 uveitis samples and 9 cataract control samples.

Results: Aqueous humour MCP-1 and PEDF levels were significantly higher in patients with infectious or non-infectious uveitis than in controls (mean (SD) 32.3 (10.7) ng/ml vs 4.48 (1.10) ng/ml vs 0.47 (0.10) ng/ml, and 8.40 (1.30) μg/ml vs 5.01 (0.92) μg/ml vs 1.32 (0.22) μg/ml, respectively, p<0.001). A positive correlation between PEDF and MCP-1 was found in patients with uveitis (r = 0.39, p<0.01).

Conclusion: The results demonstrated that aqueous humour levels of PEDF were positively associated with MCP-1 in patients with uveitis. The present observations suggest that aqueous humour levels of PEDF may be a marker of inflammation in uveitis.

Footnotes

  • Published Online First 13 December 2006

  • Competing interests: None declared.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All Versions of this Article:
    1. bjo.2006.109843v1
    2. 91/6/737 most recent

Responses

  1. Submit a response
  2. No responses published

Social bookmarking

Register for free content


Free sample
This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.