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Refractive errors in neurofibromatosis type 1 and type 2
  1. Arsen Akinci1,
  2. Golge Acaroglu2,
  3. Alev Guven3,
  4. Aydan Degerliyurt3
  1. 1Department of Pediatric Ophthalmology, Diskapi Children’s Hospital, Ankara, Turkey
  2. 2Department of Neuro-ophthalmology, Ulucanlar Eye Hospital, Ankara, Turkey
  3. 3Department of Pediatric Neurology, Diskapi Children’s Hospital, Ankara, Turkey
  1. Correspondence to: Dr A Akinci Department of Pediatric Ophthalmology, Diskapi Children’s Hospital, Dikmen Cad Yesilvadi Sok 7/5 Dikmen, 06410 Ankara, Turkey; arsenakinci{at}yahoo.com

Abstract

Objective: To document the prevalence of refractive errors in patients with neurofibromatosis type 1 (NF1) and type 2 (NF2) and to compare it with that of age- and sex-matched controls.

Methods: 82 patients with NF1, 21 patients with NF2 and 103 age- and sex-matched controls were evaluated in this prospective observational case–control study. Cycloplegic autorefraction and dilated fundus examination were performed. Myopia was defined as the spherical equivalent refraction of at least −0.50 diopters (D), hyperopia as the spherical equivalent refraction of at least 2.0 D and astigmatism as the cylinder of at least 1.0 D. Main outcome measures were refractive error, IQ, years of education, height, weight and body mass index (BMI).

Results: The prevalence of myopia was 23.1% in patients with NF1, 23.8% in patients with NF2 and 16.5% in age- and sex-matched controls. These differences were significant (p<0.03, p<0.03), and adjusting for intelligence, education, height, weight and BMI increased the significance of this finding (p<0.001, p<0.001). The prevalences of astigmatism and hyperopia were similar in both groups.

Conclusion: A high prevalence of myopia seems to be an additional feature of NF1 and NF2.

  • BMI, body mass index
  • NF1, neurofibromatosis type 1
  • NF2, neurofibromatosis type 2

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Footnotes

  • Published Online First 3 January 2007

  • Competing interests: None declared.

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