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Interferons (IFNs) and their pegylated forms (PEG-IFNs) are widely used in the treatment of viral hepatitis and some neoplasms. Although ophthalmic symptoms are common among their various side effects,1,2 abducens palsy is rarely observed. Here, we describe a case where abducens palsy developed during PEG-IFN therapy, and discuss the management.
A 65-year-old man had undergone removal of stage IV renal cell carcinoma 5 years ago. He had been managed with IFNα therapy (6×106 IU three times a week) for recurrence. Although the therapy suppressed tumour growth effectively, it had moderate side effects including influenza-like symptoms, erythema and depression. After 4 years of conventional IFN therapy, PEG-IFNα became available for the patient.
On the first day of PEG-IFN therapy (3×106 IU), the …