Article Text

PDF
Types of choroidal neovascularisation in newly diagnosed exudative age-related macular degeneration
  1. S Y Cohen1,
  2. C Creuzot-Garcher2,
  3. J Darmon3,
  4. T Desmettre4,
  5. J F Korobelnik5,
  6. F Levrat6,
  7. G Quentel1,
  8. S Paliès6,
  9. A Sanchez7,
  10. A Solesse de Gendre6,
  11. H Schluep6,
  12. M Weber8,
  13. C Delcourt9
  1. 1
    Centre Ophtalmologique d’Imagerie et de Laser, Paris, France
  2. 2
    Centre Hospitalier Universitaire, Dijon, France
  3. 3
    Centre d’Imagerie et de Laser, Nice, France
  4. 4
    Centre d’Imagerie et de Laser, Lambersart, France
  5. 5
    Centre Hospitalier Universitaire, Bordeaux, France
  6. 6
    Pfizer, Paris, France
  7. 7
    Biostatem Company, Nîmes, France
  8. 8
    Centre Hospitalier Universitaire, Nantes, France
  9. 9
    Inserm U593, Bordeaux, France; Université Victor Segalen, Bordeaux, France
  1. Salomon Y Cohen, Centre Ophtalmologique d’Imagerie et de Laser, 11 Rue Antoine Bourdelle, 75015 Paris, France; sycohen{at}club-internet.fr

Abstract

Aim: To describe the types and location of choroidal neovascularisation (CNV) in exudative age-related macular degeneration (AMD), including vascularised pigment epithelial detatchments (PED), and most recently described subtypes, such as retinal choroidal anasmostosis, also termed “retinal angiomatous proliferation” (RAP).

Methods: Prospective multicentre consecutive descriptive case series. A total of 207 consecutive cases of newly diagnosed exudative AMD undergoing fluorescein angiography (FA) were recruited by 7 French referral hospital-based or private centres. Indocyanine green angiography (ICG) also was performed, when judged necessary by investigators. Types and location of CNV were classified by two independent experts and adjudicated by a third when discordant.

Results: All patients had FA, while ICG was performed in 50% of subjects. A total of 17.6% had classic CNV only, 5.4% and 8.3% had predominantly and minimally classic CNV, respectively. Occult CNV could be classified in occult CNV without PED (32.7%) and occult CNV with PED, ie, vascularised PED (23.9%). RAP was observed in 15.1% of cases, and accounted for 30% of vascularised PED. In 5.8% of the cases there was haemorrhagic AMD and 4.8% had fibrovascular scars. Lesions were mainly subfoveal (80%). Agreement between the centre’s ophthalmologist and the final validated expert classification was moderate (κ = 0.52 for location and 0.59 for type of lesion).

Conclusion: This study confirms that newly diagnosed cases of exudative AMD are mainly occult and subfoveal. RAP appeared as a common lesion in patients with newly diagnosed exudative AMD.

Statistics from Altmetric.com

Footnotes

  • Competing interests: None declared.

  • SYC, CC-G, JD, CD, TD, JFK, GQ, MW and AS are consultants for Pfizer, France. HS, SP, ASdeG and FL are employees of Pfizer, France.

  • Abbreviations:
    AMD

    age-related macular degeneration

    CNV

    choroidal neovascularisation

    FA

    fluorescein angiography

    ICG

    indocyanine green angiography

    PED

    pigment epithelial detatchments

    RAP

    retinal angiomatous proliferation

    VEGF

    vascular endothelial growth factor

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.