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Effects of dopamine on retinal and choroidal blood flow parameters in humans
  1. Karl-Heinz Huemer1,
  2. Claudia Zawinka1,
  3. Gerhard Garhöfer1,
  4. Elisabeth Golestani1,
  5. Brigitte Litschauer2,
  6. Guido T Dorner3,
  7. Leopold Schmetterer4
  1. 1
    Departments of Clinical Pharmacology, Medical University of Vienna, Vienna A-1090, Austria
  2. 2
    Departments of Physiology and Pathophysiology, Medical University of Vienna, Vienna A-1090, Austria
  3. 3
    Departments of Ophthalmology, Medical University of Vienna, Vienna A-1090, Austria
  4. 4
    Departments of Biomedical Engineering and Physics, Medical University of Vienna, Vienna A-1090, Austria
  1. Leopold Schmetterer, Department of Clinical Pharmacology, Währinger Gürtel 18-20, A-1090 Vienna/Austria; leopold.schmetterer{at}meduniwien.ac.at

Abstract

Aim: To investigate the effect of dopamine on retinal and choroidal blood flow in humans.

Methods: We investigated the effect of two doses of intravenous dopamine (5 and 10 µg/kg/min) via a randomised double-masked crossover study in 12 healthy subjects chosen from a total of 16. Blood flow parameters in retina, optic nerve head and choroid were assessed with bi-directional laser Doppler velocimetry, laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively.

Results: Intravenous dopamine dose-dependently increased retinal blood cell velocity and fundus pulsation amplitude (p<0.001). At the highest administered dose red blood cell velocity in retinal vessels increased by 37% and fundus pulsation amplitude by 24%. By contrast, optic nerve head blood flow did not change with dopamine administration.

Conclusions: Our data indicate that dopamine has a pronounced enhancing effect on the retinal perfusion in humans. Further studies are required to establish the exact role of dopamine in the regulation of choroidal and optic nerve head blood flow.

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Footnotes

  • Competing interests: None declared.

  • Abbreviations:
    FPA

    fundus pulsation amplitude

    IOP

    intraocular pressure

    LDF

    laser Doppler flowmetry

    LDV

    (bi-directional) laser Doppler velocimetry

    OA

    ophthalmic artery

    ONH

    optic nerve head

    PR

    pulse rate

    SBP

    systolic blood pressure

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