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β-defensins are innate antimicrobial peptides found in a variety of ocular tissues and are critical to the immune response.1–3 We present a case of bilateral endophthalmitis and show the carriage of the –44CC genotype in β-defensin 1. The polymorphism has previously been linked to increased susceptibility to infection.4–7
An 80-year-old man underwent cataract surgery in the right eye complicated by a capsular tear. Within 4 days he returned with a hypopyon, painful loss of vision and reddening of the right eye. Endophthalmitis was diagnosed, an urgent vitreous tap was performed and intravitreal cetazidime and vancomycin were started. Microscopical examination revealed Gram-positive cocci, but no final growth of organisms. The right eye responded to treatment, but 1 month later a retinal detachment was diagnosed in the same eye. This was surgically repaired without complications. A year later, after an uncomplicated left cataract surgery in another hospital, the patient presented again with endophthalmitis symptoms, including hypopyon, rapid visual loss (hand movements), pain and reddening of the …
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