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Br J Ophthalmol 92:126-130 doi:10.1136/bjo.2007.122309
  • Original Article
    • Laboratory science

Indomethacin decreases optic nerve oxygen tension by a mechanism other than cyclo-oxygenase inhibition

Table 3 Effect of NSAIDs and indomethacin on arterial Pao2, Paco2 and apH
Pao2 Paco2 apH
Before indomethacin 10.7 (0.6) 7.6 (0.5) 7.43 (0.02)
After indomethacin 10.1 (1.1) 7.3 (0.6) 7.41 (0.03)
Before NSAIDs 11.3 (1.3) 7.2 (1.0) 7.42 (0.03)
After NSAIDs 10.8 (1.2) 7.4 (1.0) 7.42 (0.03)
Before NSAIDs and indomethacin 11.2 (1.8) 6.6 (0.6) 7.42 (0.04)
After NSAIDs and indomethacin 10.2 (1.1) 7.0 (0.7) 7.41 (0.06)
Before dorzolamide 11.1 (0.5) 7.2 (0.5) 7.42 (0.03)
After dorzolamide 11.4 (0.3) 8.6* (0.4) 7.34* (0.02)
  • No parameter showed any significant change after administration of any of the NSAIDs. Results are presented as the average (SD).

  • *Significant difference after the injection of 500 mg dorzolamide, which significantly increased Pco2 and decreased pH.

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