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Unremitting sympathetic ophthalmia associated with homozygous interleukin-10-1082A single nucleotide polymorphism
  1. N Glover1,
  2. J J Ah-Chan1,
  3. P Frith1,
  4. S Downes1,
  5. D Atan2
  1. 1
    Oxford Eye Hospital, Radcliffe Infirmary, Oxford, UK
  2. 2
    Bristol Eye Hospital, Bristol, UK
  1. J J Ah-Chan, Oxford Eye Hospital, The John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK; johnvic2005{at}yahoo.co.uk

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Sympathetic ophthalmia (SO) is a rare,1 bilateral, granulatomatous panuveitis following injury to one eye. Inflammation develops after the relative immune privilege of the eye is compromised, causing sensitisation to previously sequestrated uveoretinal antigens.2 Although potentially blinding, the outcome may be favourable if aggressive systemic immunosuppression is initiated early.1 3

While certain genetic variants of the human leucocyte antigen (HLA) genes influence susceptibility to SO,4 5 single nucleotide polymorphisms (SNPs) in cytokine genes influence severity of disease.7 We report a case of SO who progressively deteriorated despite early immunosuppression. She was later found to be homozygous for the interleukin-10 (IL-10)-1082A SNP.

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