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Original Article - Clinical science: The natural history of OPA1-related autosomal dominant optic atrophy
  • A C Cohn,
  • C Toomes,
  • A W Hewitt,
  • L S Kearns,
  • C F Inglehearn,
  • J E Craig,
  • D A Mackey
Br J Ophthalmol 2008;92:1333-1336 Published Online First: 24 July 2008 doi:10.1136/bjo.2007.134726

  1. Spontaneous visual improvement in dominant optic atrophy

    University of Minnesota

    Dear Editor:

    I read with interest the article by Dr. Cohn, et al regarding the natural history of autosomal dominant optic atrophy (DOA). The authors describe an average of 10-year follow up for 69 patients with genetically confirmed DOA. In their study, 6 (9%) patients enjoyed improvement in visual acuity by 2 or more lines.

    I found this surprising, and I wonder if the authors could provide further information regarding this group. Is it the opinion of the authors that these patients actually improved or that this may represent testing artifact or bias? Were they significantly younger than the rest of the cohort? Was their follow up significantly shorter? By how much did the acuities improve among this group? Was their baseline acuity more likely to come from outside records?

    Sincerely,

    Michael S Lee, MD
    Minneapolis, MN

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    Published 20 October 2008
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