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Microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers
  1. M S Kim1,
  2. C Y Choi1,
  3. J M Kim1,
  4. H R Chung1,
  5. H Y Woo2
  1. 1
    Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea
  2. 2
    Department of Laboratory Medicine, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Korea
  1. Dr C Y Choi, Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, 108, Pyeongdong, Jongnogu, Seoul, Republic of Korea; sashimi0{at}naver.com

Abstract

Background/aims: To evaluate microbial contamination of multiply used preservative-free artificial tears packed in reclosable containers after daily use.

Methods: Subjects were provided with preservative-free artificial tears (Groups 1 and 2) and artificial tears containing a preservative (Group 3). After administration three times or more per 10 h, bottles were collected, and any remaining fluid in the bottles was cultured. A risk factor analysis for microbial contamination was performed by the use of univariate and multivariate analysis.

Results: A total of 242 eye-drop bottles were evaluated. Five (2.0%) of the 242 bottles had bacterial contamination. In group 1, four (3.9%) of 102 bottles were contaminated, and identified bacteria were all coagulase-negative Staphylococcus. In group 2, one (1.0%) of 105 bottles was contaminated, and it was a Gram-negative Acinetobacter species. No bottles from group 3 showed any contamination. Based on multivariate analysis, advanced age and fingertip touch were statistically significant risk factors for microbial contamination (p<0.05).

Conclusion: Preservative-free artificial tears in reclosable containers are at risk of contamination in a daily and multiple use setting, especially in patients with a poor administering technique, which is associated with fingertip touch and advanced age.

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Footnotes

  • Competing interests: None.

  • Ethics approval: Ethics approval was provided by the Ethics Committee of Kangbuk Samsung Hospital, Seoul, Korea.

  • Patient consent: Obtained.

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