rss
Br J Ophthalmol 2008;92:1656-1660 doi:10.1136/bjo.2008.143057
  • Original Article
    • Clinical science

The role of Humphrey Matrix testing in the early diagnosis of retinopathy in type 1 diabetes

  1. M Parravano1,
  2. F Oddone1,
  3. D Mineo2,
  4. M Centofanti3,
  5. P Borboni2,
  6. R Lauro2,
  7. L Tanga1,
  8. G Manni3
  1. 1
    Fondazione G.B. Bietti per lo Studio e la Ricerca in Oftalmologia – IRCCS – Rome, Italy
  2. 2
    Dipartimento di Medicina Interna, University of Rome Tor Vergata, Italy
  3. 3
    Dipartimento di Biopatologia e Diagnostica per Immagini, University of Rome Tor Vergata, Italy
  1. Dr M Parravano, Fondazione G.B. Bietti-IRCCS, Via Livenza n 3, 00198 Rome; criparra{at}tin.it
  • Accepted 12 September 2008
  • Published Online First 1 October 2008

Abstract

Aim: The aim of the study was to investigate the role of Humphrey Matrix threshold testing in the detection of early functional retinal impairment in subjects with type 1 diabetes mellitus (DM1) without any signs of retinal vasculopathy, and to investigate the relationship between both functional and structural retinal parameters and metabolic control.

Methods: Thirty eyes of 30 subjects with DM1, with no sign of retinal vasculopathy, and 30 eyes of 30 age- and sex-matched healthy subjects were enrolled in this cross-sectional clinical study. Functional testing included Humphrey Matrix perimetry and white-on-white Humphrey visual field perimetry (HFA), while retinal nerve fibre layer (RNFL) thickness was measured by scanning laser polarimetry with variable corneal birefringence compensator (GDx VCC).

Results: Matrix mean deviation (MD) was found to be significantly reduced in subjects with DM1 compared with controls (−1.10 (SD 2.98; 95% CI −2.21 to 0.01) vs 1.37 (SD 2.11; 95% CI 0.58 to 2.16), p = 0.0005). HFA MD and pattern standard deviation (PSD) were significantly worse in subjects with DM1 compared with controls (p = 0.010 and p = 0.013 respectively). Among structural parameters, average peripapillary RNFL thickness was reduced in DM1 subjects (p = 0.006). Matrix MD and HFA MD and PSD, and average peripapillary and superior RNFL, were significantly reduced in subjects with DM1 with HbA1c ≥7% compared with controls.

Conclusions: Functional and structural retinal testing by Humphrey Matrix and GDx VCC could be useful for the identification of early retinal impairment in people with DM1 with no sign of retinal vasculopathy.

Footnotes

  • Competing interests: None.

  • Ethics approval: The study was carried out in accordance with the Declaration of Helsinki and was approved by the ethics committee of the institution.

  • Patient consent: Obtained.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All Versions of this Article:
    1. bjo.2008.143057v1
    2. 92/12/1656 most recent

Responses

  1. Submit a response
  2. No responses published

Social bookmarking

Register for free content


Free sample
 This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of BJO.
View free sample issue >>

Free archive
The full back archive is now available for BJO. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006, back to volume 1 issue 1.
Register to access the free archive >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.