Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium
- S Michels1,2,
- M Pircher3,
- W Geitzenauer1,
- C Simader1,
- E Götzinger3,
- O Findl4,
- U Schmidt-Erfurth1,
- C K Hitzenberger3
- 1Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
- 2Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland
- 3Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria
- 4Moorfields Eye Hospital, London, UK
- S Michels, Department of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, 8091 Zürich, Switzerland;
- Accepted 12 October 2007
Objectives: To evaluate pathological changes of retinal pigment epithelium (RPE) by polarisation-sensitive optical coherence tomography (PS-OCT).
Methods: Forty-four eyes (22 patients) with significant pathologies of the RPE were evaluated using PS-OCT. A transversal scanning time domain OCT system was used for two-dimensional cross-sectional imaging of retinal polarisation properties.
Results: The RPE scrambles the polarisation state of backscattered light (ie, acts as a depolarising layer), while the polarisation state of transmitted light is maintained. In patients with RPE pathologies irregularity, elevation, thickening or absence of the RPE is readily visualised by exploiting the depolarisation information. Polarisation scrambling in the sensory retina can be found in cases with advanced dry age-related macular degeneration. Sclera and fibrosis show characteristic birefringence in PS-OCT.
Conclusion: PS-OCT allows tissue identification based on polarisation scrambling and birefringence, providing additional information on RPE pathologies. It is a promising new tool for diagnosis, disease follow-up and evaluation of new treatment strategies.
Competing interests: None.
Funding: Austrian Science Fund FWF-Grant P16776-N02.