Article Text

PDF
Supranumerary optic disc vessels may indicate reduced systemic angiogenesis in Down syndrome
  1. C F Parsa,
  2. Z Almer
  1. Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  1. C F Parsa, Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Wilmer 233, 600 North Wolfe Street, Baltimore, MD 21287-9028, USA; cparsa{at}jhmi.edu

Statistics from Altmetric.com

A markedly increased number of retinal blood vessels at the level of the optic disc is often present in Down syndrome.1 Additional characteristics of trisomy 21 include a low incidence of proliferative changes in those with longstanding diabetic retinopathy2 and a markedly low incidence of solid cancerous growth.3 A mechanism is proposed to link these and other findings.

Angiogenesis, as opposed to vasculogenesis (the de novo formation of vessels via differentiation of endothelial precursor cells), consists of new vessel formation by budding off from existing vessels.4 5 During embryogenesis this occurs mainly in the eye and in the kidney.5 6 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.