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Bilateral MALT-type ocular adnexal lymphoma with marginal zone lymphoma leukaemic cells and ophthalmological diffuse large B cell lymphoma
  1. R Sahli1,
  2. D Canioni2,
  3. J Couturier3,
  4. G Soler4,
  5. C Mathiot5,
  6. O Galatoire6,
  7. L Lumbroso-Le Rouïc7,
  8. M Puttermann2,
  9. O Hermine,
  10. P Validire1,
  11. S Morax6,
  12. N Brousse2,
  13. D Decaudin1,8
  1. 1
    Department of Clinical Haematology, Institut Curie, Paris, France
  2. 2
    Department of Pathology, Necker-Enfants maladies Hospital, Paris, France
  3. 3
    Department of Tumour Biology, Institut Curie, Paris, France
  4. 4
    Department of Haematological Cytogenetics, Necker-Enfants Malades Hospital, Paris, France
  5. 5
    Department of Ophthalmology, Institut Curie, Paris, France
  6. 6
    Department of Ophthalmology, Fondation Rothschild, Paris, France
  7. 7
    Department of Clinical Haematology, Necker-Enfants Malades Hospital, Paris, France
  8. 8
    Laboratory of Preclinical Investigation, Institute Curie, Paris
  1. Dr Didier Decaudin, Service d’Hématologie Clinique, Laboratory of Preclinical Investigation, Institut Curie, 26 rue d’Ulm, 75248 Paris cedex 05, France; didier.decaudin{at}curie.net

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Marginal zone lymphomas (MZL), clearly defined in the WHO classification of lymphoid neoplasms,1 comprise three distinct entities depending on the site of involvement: extranodal MZL or mucosa associated lymphoid tissue (MALT) type, splenic MZL (with or without villous lymphocytes) and nodal MZL. Lacrimal gland and intraorbital sites are the most frequent ophthalmological sites of MALT-type ocular adnexal lymphomas (OAL).2 We report the unusual case of a patient with bilateral intraorbital MALT-type lymphoma with MZL cells in the peripheral blood and ophthalmologic large B cell lymphoma histological transformation at the time of initial diagnosis.

Case report

A 60-year-old woman with a history …

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