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Br J Ophthalmol 92:928-932 doi:10.1136/bjo.2007.133967
  • Original Article
    • Clinical science

Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis

Table 3 PCR results for each herpes virus genome in patients with uveitis
Herpes virus Clinical diagnosis PCR-positive*/total no of patients
HSV1 Herpetic keratouveitis 2/7†
Herpetic anterior uveitis 3/16
Acute retinal necrosis 2/16
Others 0/61
HSV2 Acute retinal necrosis 3/16
Others 0/84
VZV Herpetic anterior uveitis 10/16
Acute retinal necrosis 11/16
Others 0/68
EBV Idiopathic uveitis 1/26
Herpetic anterior uveitis (VZV) 2/16
Acute retinal necrosis (VZV) 2/16
Intraocular lymphoma 1/12
Others 0/30
CMV Herpetic anterior uveitis 3/16
Cytomegalovirus retinitis 1/1
Others 0/83
HHV6 Idiopathic uveitis 1/26
Others 0/74
HHV7 – 0/100
HHV8 – 0/100

  • *Detection of HHV-DNA by both multiplex PCR and real-time PCR.

  • †In the seven patients with keratouveitis, our PCR system detected HSV1-DNA in two patients.

  • CMV, cytomegalovirus; EBV, Epstein–Barr virus; HHV, human herpes virus; HSV, herpes simplex virus; VZV, Varicella-zoster virus.

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