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Br J Ophthalmol 92:936-940 doi:10.1136/bjo.2007.132357
  • Original Article
    • Clinical science

Marked vascular changes of polypoidal choroidal vasculopathy after photodynamic therapy

  1. T Wakabayashi,
  2. F Gomi,
  3. M Sawa,
  4. M Tsujikawa,
  5. Y Tano
  1. Department of Ophthalmology, Osaka University Medical School, Suita, Japan
  1. Dr F Gomi, Department of Ophthalmology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan; fgomi{at}ophthal.med.osaka-u.ac.jp
  • Accepted 19 March 2008

Abstract

Aims: To clarify vascular changes of polypoidal choroidal vasculopathy (PCV) after photodynamic therapy (PDT).

Methods: Thirty-one eyes underwent PDT with verteporfin and were followed every 3 months with indocyanine green angiography (ICGA) using confocal scanning ophthalmoscope and optical coherence tomography (OCT) for over 15 months and the findings recorded.

Results: The mean follow-up period was 19.2 months. Regression of the polypoidal lesions were confirmed once in 29 eyes (94%) on ICGA and OCT. Some lesions recurred at the initial regions (n = 5 eyes), at different regions connected to the branching vascular network (n = 4 eyes), and at both regions (n = 1 eye) (mean 11.4 (SD 1.9) months) after initial PDT. The branching vascular network remained in all eyes and enlarged in 13 eyes (42%) at the final visit. The vascular features of residual branching vascular networks changed (n = 7 eyes); fibrinous subretinal exudation developed (n = 4 eyes), and the retinal pigment epithelium was elevated similar to vascularised pigment epithelial detachment (n = 3 eyes).

Conclusion: Polypoidal lesions of PCV are treatable with PDT; however, they often recur. The branching vascular networks do not regress and allow the recurrence of polypoidal lesions at the network termini. Alterations of the vascular features may occur; careful observation is needed after PDT.

Footnotes

  • Competing interests: None.

  • Ethics approval: Ethics approval was obtained.

  • Patient consent: All patients provided informed consent.