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False negative antibody-based HLA-A29 typing in two patients with birdshot chorioretinopathy
  1. J D Wender,
  2. A D Fu,
  3. J M Jumper,
  4. H R McDonald,
  5. R N Johnson,
  6. E T Cunningham, Jr
  1. The San Francisco Retinal Foundation, and The Pacific Vision Foundation, California Pacific Medical Center, San Francisco, CA, USA
  1. Dr E T Cunningham, Jr, West Coast Retina Medical Group, 185 Berry Street, San Francisco, CA 94107, USA; emmett_cunningham{at}yahoo.com

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A strong association between birdshot chorioretinopathy and HLA-A29 expression has been well established.1 In fact, some have suggested that HLA-A29 expression is essential to make the diagnosis of birdshot chorioretinopathy. Such a strong association makes accurate HLA-A29 subtyping quite important in patients suspected of having this entity. Herein, we describe two patients with birdshot chorioretinopathy in whom initial testing for HLA-A29 expression using antibody-based methods was negative and subsequent testing using more sensitive and specific PCR-based techniques was positive.

Case 1

A 45-year-old Caucasian man with a history of psoriatic skin lesions presented with worsening vision, floaters, and nyctalopia affecting both eyes for 2 months prior to presentation. Best corrected visual acuity was 20/25 …

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