rss
Br J Ophthalmol 2008;92:1244-1247 doi:10.1136/bjo.2008.144196
  • Original Article
    • Clinical science

Treatment of peripapillary choroidal neovascular membranes with intravitreal bevacizumab

  1. M S Figueroa1,2,
  2. S Noval2,3,
  3. I Contreras1,2
  1. 1
    Hospital Universitario Ramón y Cajal, Madrid, Spain
  2. 2
    Vissum Corporación Oftalmológica, Madrid, Spain
  3. 3
    Hospital Universitario La Paz, Madrid, Spain
  1. Dr I Contreras, Departamento de Oftalmología, Hospital Ramón y Cajal, Ctra. Colmenar Viejo Km 9,100, Madrid 28034, Spain; inescon3{at}yahoo.com
  • Accepted 22 June 2008
  • Published Online First 11 July 2008

Abstract

Aims: To evaluate the effect of intravitreal injections of bevacizumab in the treatment of peripapillary choroidal neovascular membranes.

Methods: Interventional case series of patients with active peripapillary choroidal neovascular membranes. Ophthalmological examination included best-corrected visual acuity, fundus biomicroscopy, fluorescein angiography and optical coherence tomography (OCT). Bevacizumab injections (1.25 mg) were repeated monthly for the first 3 months. Re-treatment was considered if there were any signs of membrane activity.

Results: Six eyes of five patients with peripapillary choroidal membranes were included in the study with a mean follow-up of 13 months (range 6 to 16). Bevacizumab was used as the initial treatment in four eyes and to manage recurrences after surgery in the other two. In five eyes, three injections of bevacizumab led to a complete resolution of leakage on fluorescein angiography and OCT. In one eye, membrane activity persisted despite six injections of bevacizumab. Visual acuity improved in five eyes with a mean improvement of four lines (range: 2–10 lines). It deteriorated only in the eye that did not respond to treatment.

Conclusions: The results of this case series suggest that the intravitreal injection of bevacizumab may be an effective treatment for peripapillary choroidal membranes.

Footnotes

  • Competing interests: None.

  • Ethics approval: The study was approved by the ethics committee of the ”Hospital Universitario Ramón y Cajal,„ Madrid, Spain.

  • Patient consent: Obtained.

This Article

  1. Abstract
  2. Full text
  3. PDF
  4. All versions of this article:
    1. bjo.2008.144196v1
    2. 92/9/1244 most recent

Responses

  1. Submit a response
  2. No responses published

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.