Article Text

PDF
Recurrence characteristics in European patients with ocular toxoplasmosis
  1. J G Garweg1,2,
  2. J N Scherrer3,
  3. M Halberstadt1,4
  1. 1
    Swiss Eye Institute, Clinic for Vitreoretinal Disease, Bern, Switzerland
  2. 2
    Medical Faculty, University of Bern, Bern, Switzerland
  3. 3
    Department of Ophthalmology, Kantonsspital St. Gallen, Switzerland
  4. 4
    Department of Ophthalmology, Medizinische Hochschule Hannover, Germany
  1. Professor J G Garweg, Swiss Eye Institute, Berner Augenklinik am Lindenhofspital, Bremgartenstrasse 119, CH 3012 Bern, Switzerland; justus.garweg{at}swiss-eye-institute.com

Abstract

Background: The risk of function loss after each episode of ocular toxoplasmosis (OT) supports efforts to improve our understanding of the disease.

Patients and methods: 139 patients with OT were contacted retrospectively and requested to complete a questionnaire addressing course and activity of their disease. This information was compared with that retrieved from their medical records. Sixty-three patients completed the questionnaire and were included in the study. They were allocated according to their median age to one of two groups (group 1: <20.9 years; group 2: ⩾20.9 years).

Results: The mean reported age at the time of first ocular manifestation was 23.9 (median 20.9, range 0 to 70.5; SD 12.9) years. The clinical diagnosis was made 3.5 years later (p = 0.0008). The follow-up time was 6.5 (median 5.0; range 0.5 to 49.9; SD 7.6) years. The recurrence rate was higher in patients below 20.9 years (66%; n = 35) than in older patients (39%; n = 28; χ2 test, p<0.05). Patients reporting only one episode were older at first manifestation (29.6 (median 25.6; range 10.6 to 70.5; SD 14.3) years; n = 29) than those reporting two episodes (17.9 (median 19.5; range 5.9 to 33.9; SD 7.8) years; n = 15 (p<0.05)). The proportion of patients who developed a recurrence was 54–63% after each episode without a tendency to enlarge, and the interval between successive episodes remained stable between 1.0 and 1.7 years for the first three recurrences.

Conclusion: Younger OT patients carry a higher risk of developing a recurrence than older ones. After each episode, two-thirds of all OT patients will develop another one.

Statistics from Altmetric.com

Footnotes

  • Competing interests: None.

  • Ethics approval: Ethics approval was obtained from the Local Institutional Ethical Committee.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • At a glance
    Harminder S Dua Arun D Singh