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Br J Ophthalmol 2009;93:1337-1340 doi:10.1136/bjo.2008.149195
  • Original Article
  • Clinical science

Macular hole formation after macular haemorrhage associated with rupture of retinal arterial macroaneurysm

  1. N Sagara,
  2. T Kawaji,
  3. Y Koshiyama,
  4. Y Inomata,
  5. M Fukushima,
  6. H Tanihara
  1. Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan
  1. Correspondence to Dr T Kawaji, Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan; kawag{at}white.plala.or.jp
  • Accepted 24 April 2009
  • Published Online First 10 June 2009

Abstract

Aim: To investigate the frequency and risk factors of macular hole (MH) formation after rupture of a retinal arterial macroaneurysm.

Methods: Fifty-six eyes from 56 patients with rupture of a retinal arterial macroaneurysm with or without an MH (MH and non-MH groups, respectively) were reviewed. Frequency and risk factors related to MH formation were assessed, with risk factors including age; sex; distance from the macroaneurysm to the fovea; incidence of haemorrhages involving the macula such as preretinal, subinternal limiting membrane (sub-ILM), subretinal and vitreous; and vitreous surgery. MH formation in these patients was recorded and analysed.

Results: Of the 56 eyes reviewed, seven (12.5%) had an MH after rupture of the retinal arterial macroaneurysm. The incidence of subretinal and sub-ILM haemorrhages involving the macula was significantly greater in the MH group than in the non-MH group (p = 0.037 and 0.045, respectively).

Conclusion: These results suggest that the presence of subretinal and sub-ILM haemorrhages after rupture of a retinal arterial macroaneurysm may contribute to formation of an MH.

Footnotes

  • Funding The authors’ work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan and the Ministry of Health and Welfare, Japan.

  • Competing interests None.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

  • Ethics approval Ethics approval was provided by the Institutional Review Board of Kumamoto University.

  • Patient consent Obtained.

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