Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration
- K Yi1,2,3,
- M Mujat1,4,5,
- B H Park1,4,
- W Sun4,6,
- J W Miller1,7,
- J M Seddon8,
- L H Young1,7,
- J F de Boer1,4,9,
- T C Chen1,2
- 1Harvard Medical School, Boston, Massachusetts, USA
- 2Massachusetts Eye and Ear Infirmary, Glaucoma Service, Boston, Massachusetts, USA
- 3Kangnam Sacred Heart Hospital, Hallym University, Seoul, Korea
- 4Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts, USA
- 5Physical Sciences Inc., Andover, Massachusetts, USA
- 6Boston University, Department of Physics, Boston, Massachusetts, USA
- 7Massachusetts Eye and Ear Infirmary, Retina Service, Boston, Massachusetts, USA
- 8Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
- 9Department of Physics and Astronomy, VU University, Amsterdam, The Netherlands
- Dr T C Chen, Glaucoma Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA;
- Accepted 14 May 2008
- Published Online First 12 August 2008
Background/aims: To demonstrate how spectral domain optical coherence tomography (SDOCT) can better evaluate drusen and associated anatomical changes in eyes with non-neovascular age-related macular degeneration (AMD) compared with time domain optical coherence tomography (TDOCT).
Methods: Images were obtained from three eyes of three patients with AMD using an experimental SDOCT system. Both a titanium–sapphire (Ti:sapphire) laser and a superluminescent diode (SLD) were used as a broadband light source to achieve cross-sectional images of the retina. A qualitative and quantitative analysis was performed for structural changes associated with non-neovascular AMD. An automated algorithm was developed to analyse drusen area and volume from SDOCT images. TDOCT was performed using the fast macular scan (StratusOCT, Carl Zeiss Meditec, Dublin, California).
Results: SDOCT images can demonstrate structural changes associated with non-neovascular AMD. A new SDOCT algorithm can determine drusen area, drusen volume and proportion of drusen.
Conclusions: With new algorithms to determine drusen area and volume and its unprecedented simultaneous ultra-high speed ultra-high resolution imaging, SDOCT can improve the evaluation of structural abnormalities in non-neovascular AMD.
Funding: This paper was partially supported by the National Institutes of Health, Bethesda, Maryland (RO1EY014975, R01-RR19768). Nidek sponsors JFB’s research. Patents in spectral domain optical coherence tomography: JFB, MM, BHP.
Competing interests: None.
Ethics approval: Ethics approval was provided by the Massachusetts Eye and Ear Infirmary and Massachusetts General Hospital Institutional Review Boards.
Patient consent: Obtained.
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