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Br J Ophthalmol 93:219-224 doi:10.1136/bjo.2008.140186
  • Original Article
    • Clinical science

Effect of latanoprost and timolol on the histopathology of the human conjunctiva

Table 2 Analysis of extracellular conjunctival tissue changes: area occupied by collagen fibres, amorphous material and empty spaces in the subepithelial and deep layer in the control-, timolol- and latanoprost group
Group Collagen fibres Amorphous material Empty spaces
Subepithelial layer
    Control 40.3 (15.3) 30.9 (12.8) 28.8 (20.2)
    Timolol 43.3 (17.4) (p>0.05) 43.3 (13.2) (p<0.001) 13.4 (9.5) (p<0.001)
    Latanoprost 42.9 (13.2) (p>0.05) 38.1 (10.1) (p<0.001) 19.0 (10.5) (p<0.01)
Deep layer
    Control 33.5 (14.6) 26.6 (12.2) 39.9 (20.9)
    Timolol 36.6 (13.2) (p>0.05) 35.1 (9.8) (p<0.001) 32.8 (15.1) (p<0.05)
    Latanoprost 31.8 (10.4) (p>0.05) 31.1 (10.4) (p<0.001) 32.7 (14.9) (p<0.05)
  • Data are presented as mean percentage (SD) (p values) relative to control group are indicated below.

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