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From questions on page 282

1. WHAT IS THE DIFFERENTIAL DIAGNOSIS IN A CHILD WITH JIA-RELATED UVEITIS AND SUDDEN VISUAL IMPAIRMENT? WHICH DIAGNOSTIC TOOLS MAY BE INDICATED?

In children with JIA-related uveitis, several different causes of visual impairment, such as progression of cataract, vitreitis or CMO should be considered and ruled out. B-Scan ultrasonography and OCT may be helpful, when a worsening of the visual function cannot be explained by the ophthalmological examination alone. In patients treated with anti-TNFα agents, depending on the risk of demyelinating diseases involving the optic nerves, other complementary diagnostic tools, such as VEPs, AP and MRI, should be considered and tailored on the clinical situation.

2. WHAT IS THE ROLE OF VEPS IN PATIENTS TREATED WITH ANTI-TNFα AGENTS?

The finding of abnormal VEPs supports the diagnosis of optic nerve involvement. In particular, the reduced amplitude and prolonged latency of P100 component, with asymmetry between the eyes on flash VEP and pattern reversal VEP …

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